Comparison of effects of anti-angiogenic agents in the zebrafish efficacy–toxicity model for translational anti-angiogenic drug discovery

@inproceedings{Chimote2014ComparisonOE,
  title={Comparison of effects of anti-angiogenic agents in the zebrafish efficacy–toxicity model for translational anti-angiogenic drug discovery},
  author={Geetanjali Chimote and Jayasree Sreenivasan and Nilambari Pawar and Jyothi Subramanian and Hariharan Sivaramakrishnan and Somesh Sharma},
  booktitle={Drug design, development and therapy},
  year={2014}
}
BACKGROUND Anti-angiogenic therapy in certain cancers has been associated with improved control of tumor growth and metastasis. Development of anti-angiogenic agents has, however, been saddled with higher attrition rate due to suboptimal efficacy, narrow therapeutic windows, or development of organ-specific toxicities. The aim of this study was to evaluate the translational ability of the zebrafish efficacy-toxicity model to stratify anti-angiogenic agents based on efficacy, therapeutic windows… CONTINUE READING

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