Comparison of doxorubicin- and MEN 10755-induced long-term progressive cardiotoxicity in the rat.

@article{Cirillo2000ComparisonOD,
  title={Comparison of doxorubicin- and MEN 10755-induced long-term progressive cardiotoxicity in the rat.},
  author={Rocco Cirillo and Giuseppe Sacco and S Venturella and Joseph Brightwell and Antonio Giachetti and Stefano Manzini},
  journal={Journal of cardiovascular pharmacology},
  year={2000},
  volume={35 1},
  pages={100-8}
}
The delayed functional cardiotoxic effects of repeated treatment with the new disaccharide anthracycline MEN 10755 and doxorubicin (1.5 mg/kg, i.v., once a week for 5 consecutive weeks) were investigated in the rat. Changes were assessed (2 days and 4 and 13 weeks after the last treatment) in ECG morphology, hemodynamics, in vivo left ventricular contractile responses to beta-adrenergic stimulation, and histopathology of both atria and ventricles. Doxorubicin induced significant and progressive… CONTINUE READING

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