• DOI:10.1056/NEJMoa0907118
Corpus ID: 2208904

Comparison of dopamine and norepinephrine in the treatment of shock.

@article{Backer2010ComparisonOD,
  title={Comparison of dopamine and norepinephrine in the treatment of shock.},
  author={D. De Backer and P. Biston and J. Devriendt and C. Madl and D. Chochrad and C. Aldecoa and A. Brasseur and P. Defrance and P. Gottignies and J. Vincent},
  journal={The New England journal of medicine},
  year={2010},
  volume={362 9},
  pages={
          779-89
        }
}

• D. De Backer, P. Biston, +7 authors J. Vincent
• Published 2010
• Medicine
• The New England journal of medicine

BACKGROUND Both dopamine and norepinephrine are recommended as first-line vasopressor agents in the treatment of shock. There is a continuing controversy about whether one agent is superior to the other. METHODS In this multicenter, randomized trial, we assigned patients with shock to receive either dopamine or norepinephrine as first-line vasopressor therapy to restore and maintain blood pressure. When blood pressure could not be maintained with a dose of 20 microg per kilogram of body… Expand

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