Comparison of dissolution profiles of Ibuprofen pellets.

@article{Costa2003ComparisonOD,
  title={Comparison of dissolution profiles of Ibuprofen pellets.},
  author={Flavia O. Costa and Jo{\~a}o Jos{\'e} Sim{\~o}es de Sousa and Alberto A C C Pais and S J Formosinho},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2003},
  volume={89 2},
  pages={199-212}
}
In this work we use both model dependent and independent techniques to assess the difference between dissolution profiles in which ibuprofen, in the form of uncoated pellets, is used as a model drug. The choice of a proper regression function, the relevance of the estimated parameters and the influence of the choice of dissolution points in the assessment of differences is discussed. The results obtained via mean dissolution times (MDT) and fit-factors (f(1) and f(2)) are also discussed and a… CONTINUE READING

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