Comparison of disposition parameters of quinidine and quinine in the rat.


The difference in disposition of quinidine (Qd) and its diastereomer quinine (Qn) after intravenous administration was examined in rats at doses ranging from 5 to 20 mg/kg. Dose-dependent kinetics in total clearance and in distribution volume of tissue based on a two-compartment model was observed for Qd; there was no evidence of nonlinearity for Qn… (More)


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