Comparison of different methodological implementations of voxel-based morphometry in neurodegenerative disease.

@article{Senjem2005ComparisonOD,
  title={Comparison of different methodological implementations of voxel-based morphometry in neurodegenerative disease.},
  author={Matthew L. Senjem and Jeffrey L. Gunter and Maria M. Shiung and Ronald C. Petersen and Clifford R. Jack},
  journal={NeuroImage},
  year={2005},
  volume={26 2},
  pages={600-8}
}
Voxel-based morphometry (VBM) is a popular method for probing inter-group differences in brain morphology. Variation in the detailed implementation of the algorithm, however, will affect the apparent results of VBM analyses and in turn the inferences drawn about the anatomic expression of specific disease states. We qualitatively assessed group comparisons of 43 normal elderly control subjects and 51 patients with probable Alzheimer's disease, using five different VBM variations. Based on the… CONTINUE READING