Comparison of different commercially available cationic liposome-DNA lipoplexes: Parameters influencing toxicity and transfection efficiency.

@article{Masotti2009ComparisonOD,
  title={Comparison of different commercially available cationic liposome-DNA lipoplexes: Parameters influencing toxicity and transfection efficiency.},
  author={Andrea Masotti and Giuseppe Mossa and Cesare Cametti and Giancarlo Ortaggi and Alberto Bianco and Nick Del Grosso and Daniela Malizia and Claudio Esposito},
  journal={Colloids and surfaces. B, Biointerfaces},
  year={2009},
  volume={68 2},
  pages={136-44}
}
Lipid-DNA complexes (lipoplexes) are widely used, since several years, as gene carriers. However, their transfection efficiency, both in vitro and in vivo, depends, in a rather complex way, on different interconnected parameters, ranging from the chemical composition of the lipid components to the size and size distribution of the complexes and, moreover, to the composition of the suspending medium. In this paper, we have investigated the behavior of nine different commercially available… CONTINUE READING
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