Comparison of developmental toxicology of aspirin (acetylsalicylic acid) in rats using selected dosing paradigms.

@article{Gupta2003ComparisonOD,
  title={Comparison of developmental toxicology of aspirin (acetylsalicylic acid) in rats using selected dosing paradigms.},
  author={U. I. Gupta and Jon C. Cook and Melissa S. Tassinari and Mark E Hurtt},
  journal={Birth defects research. Part B, Developmental and reproductive toxicology},
  year={2003},
  volume={68 1},
  pages={27-37}
}
BACKGROUND Analysis of the literature for nonsteroidal anti-inflammatory drugs (NSAIDs) suggests that a low incidence of developmental anomalies occurs in rats given NSAIDs on specific days during organogenesis. Aspirin (acetylsalicylic acid [ASA]), an irreversible cyclooxygenase 1 and 2 inhibitor, induces developmental anomalies when administered to Wistar rats on gestational day (GD) 9, 10, or 11 (Kimmel CA, Wilson JG, Schumacher HJ. Teratology 4:15-24, 1971). There are no published ASA… CONTINUE READING

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