Comparison of data‐acquisition methods for the identification and quantification of histone post‐translational modifications on a Q Exactive HF hybrid quadrupole Orbitrap mass spectrometer

@inproceedings{Cole2019ComparisonOD,
  title={Comparison of data‐acquisition methods for the identification and quantification of histone post‐translational modifications on a Q Exactive HF hybrid quadrupole Orbitrap mass spectrometer},
  author={Jim E. Cole and Eric J. Hanson and David R. C. James and David H Dockrell and Mark J Dickman},
  booktitle={Rapid communications in mass spectrometry : RCM},
  year={2019}
}
RATIONALE Histone PTMs play key roles in regulating eukaryotic gene expression. Mass spectrometry (MS) has emerged as a powerful method to characterize and quantify histone PTMs as it allows unbiased identification and quantification of multiple histone PTMs including combinations of the modifications present. METHODS In this study we compared a range of data acquisition methods for the identification and quantification of the histone PTMs using a Q Exactive HF Orbitrap. We compared three… CONTINUE READING
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