Comparison of controlled-release and immediate-release oxycodone tablets in patients with cancer pain.

@article{Kaplan1998ComparisonOC,
  title={Comparison of controlled-release and immediate-release oxycodone tablets in patients with cancer pain.},
  author={Rosandra N. Kaplan and W. Parris and Marc L. Citron and Donna S. Zhukovsky and Robert F Reder and Barbara J. Buckley and R F Kaiko},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={1998},
  volume={16 10},
  pages={3230-7}
}
PURPOSE This study compared the clinical efficacy of oxycodone hydrochloride controlled-release (CR) tablets administered every 12 hours with immediate-release (IR) oxycodone tablets administered four times daily in patients with cancer-related pain. PATIENTS AND METHODS Cancer patients who required therapy for moderate to severe pain were randomized to CR oxycodone every 12 hours (n=81) or IR oxycodone four times daily (n=83) for 5 days in a multicenter, double-blind study. Pain intensity… CONTINUE READING