Comparison of competitive ligand-binding assay and bioassay formats for the measurement of neutralizing antibodies to protein therapeutics.

@article{Finco2011ComparisonOC,
  title={Comparison of competitive ligand-binding assay and bioassay formats for the measurement of neutralizing antibodies to protein therapeutics.},
  author={Deborah Finco and Daniel J Baltrukonis and Adrienne Clements-Egan and Kathy Delaria and George R. Gunn and John A. Lowe and Mauricio Maia and Teresa W T Wong},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2011},
  volume={54 2},
  pages={351-8}
}
Administration of biological therapeutic proteins can lead to unwanted immunogenicity in recipients of these products. The assessment and characterization of such immune reactions can be helpful to better understand their clinical relevance and how they relate to patient safety and therefore, have become an integral part of a product development program for biological therapeutics. Testing for anti-drug antibodies (ADA) to biological/biotechnology-derived therapeutic proteins generally follows… CONTINUE READING

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