Comparison of chloroguanide and mephenytoin for the in vivo assessment of genetically determined CYP2C19 activity in humans.

@article{Partovian1995ComparisonOC,
  title={Comparison of chloroguanide and mephenytoin for the in vivo assessment of genetically determined CYP2C19 activity in humans.},
  author={C Partovian and Evelyne Jacqz-Aigrain and Annick Keundjian and P. Jaillon and Christian Funck-Brentano},
  journal={Clinical pharmacology and therapeutics},
  year={1995},
  volume={58 3},
  pages={
          257-63
        }
}
OBJECTIVES The main objective of this study was to examine the relations between chloroguanide (proguanil) and mephenytoin metabolic ratios to determine whether or not chloroguanide could replace mephenytoin as a probe for the indirect in vivo measurement of CYP2C19 activity. An additional objective was to examine the interactions between chloroguanide, omeprazole, and mephenytoin, which are three substrates of CYP2C19. METHODS Twenty healthy volunteers received 200 mg chloroguanide orally on… CONTINUE READING
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