Comparison of chloral hydrate and midazolam by mouth as premedicants in children undergoing otolaryngological surgery.

@article{Saarnivaara1988ComparisonOC,
  title={Comparison of chloral hydrate and midazolam by mouth as premedicants in children undergoing otolaryngological surgery.},
  author={Laila Saarnivaara and Leena Lindgren and U M Klemola},
  journal={British journal of anaesthesia},
  year={1988},
  volume={61 4},
  pages={390-6}
}
Chloral hydrate 25, 50 or 75 mg kg-1 or midazolam 0.4, 0.5 or 0.6 mg kg-1, all given by mouth in combination with atropine 0.03 mg kg-1, were compared as premedication in 248 children in a randomized, double-blind study. Chloral hydrate was significantly less palatable than midazolam. The anxiolytic effect of chloral hydrate 75 mg kg-1 was "good" in children younger than 5 yr, whereas the other doses of chloral hydrate, and all doses of midazolam, provided only "fair" anxiolysis in this age… CONTINUE READING