Comparison of cerebrospinal fluid levels of tau and Aβ 1-42 in Alzheimer disease and frontotemporal degeneration using 2 analytical platforms.

@article{Irwin2012ComparisonOC,
  title={Comparison of cerebrospinal fluid levels of tau and Aβ 1-42 in Alzheimer disease and frontotemporal degeneration using 2 analytical platforms.},
  author={David J Irwin and Corey T McMillan and Jon B. Toledo and Steven E Arnold and Leslie M. Shaw and Li-San Wang and Vivianna M Van Deerlin and Virginia M-Y Lee and John Q. Trojanowski and Murray Grossman},
  journal={Archives of neurology},
  year={2012},
  volume={69 8},
  pages={
          1018-25
        }
}
OBJECTIVE To use values of cerebrospinal fluid tau and β-amyloid obtained from 2 different analytical immunoassays to differentiate Alzheimer disease (AD) from frontotemporal lobar degeneration (FTLD). DESIGN Cerebrospinal fluid values of total tau (T-tau) and β-amyloid 1-42 (Aβ 1-42) obtained using the Innotest enzyme-linked immunosorbent assay were transformed using a linear regression model to equivalent values obtained using the INNO-BIA AlzBio3 (xMAP; Luminex) assay. Cutoff values… CONTINUE READING
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