Comparison of cefprozil and cefaclor pharmacokinetics and tissue penetration.

  title={Comparison of cefprozil and cefaclor pharmacokinetics and tissue penetration.},
  author={Rashmi H. Barbhaiya and Umesh A. Shukla and Christina Gleason and Wen Chyi Shyu and Richard B. Wilber and Kenneth A. Pittman},
  journal={Antimicrobial agents and chemotherapy},
  volume={34 6},
The pharmacokinetics and tissue penetration, as judged by skin blister fluid, of cefprozil and cefaclor were examined in 12 healthy male volunteers. Doses of 250 and 500 mg of each drug were given to fasting subjects in a crossover fashion. Serially obtained plasma, skin blister fluid, and urine samples were analyzed for cefprozil or cefaclor by validated high-pressure liquid chromatographic methods. After oral administration of 250 and 500 mg of cefprozil, mean concentrations in plasma rose to… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 12 extracted citations

Comparison of cefprozil and cefaclor for treatment of acute urinary tract infections in women.

Antimicrobial agents and chemotherapy • 1991
View 5 Excerpts
Highly Influenced

Comparative studies of cefprozil in the management of skin and soft-tissue infections

European Journal of Clinical Microbiology and Infectious Diseases • 1994

Similar Papers

Loading similar papers…