Comparison of cefprozil and cefaclor pharmacokinetics and tissue penetration.

@article{Barbhaiya1990ComparisonOC,
  title={Comparison of cefprozil and cefaclor pharmacokinetics and tissue penetration.},
  author={Rashmi H. Barbhaiya and Umesh A. Shukla and Christina Gleason and Wen Chyi Shyu and Richard B. Wilber and Kenneth A. Pittman},
  journal={Antimicrobial agents and chemotherapy},
  year={1990},
  volume={34 6},
  pages={1204-9}
}
The pharmacokinetics and tissue penetration, as judged by skin blister fluid, of cefprozil and cefaclor were examined in 12 healthy male volunteers. Doses of 250 and 500 mg of each drug were given to fasting subjects in a crossover fashion. Serially obtained plasma, skin blister fluid, and urine samples were analyzed for cefprozil or cefaclor by validated high-pressure liquid chromatographic methods. After oral administration of 250 and 500 mg of cefprozil, mean concentrations in plasma rose to… CONTINUE READING
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