Comparison of cathepsin protease activities in brain tissue from normal cases and cases with Alzheimer's disease, Lewy body dementia, Parkinson's disease and Huntington's disease

@article{Mantle1995ComparisonOC,
  title={Comparison of cathepsin protease activities in brain tissue from normal cases and cases with Alzheimer's disease, Lewy body dementia, Parkinson's disease and Huntington's disease},
  author={D. Ray Mantle and Gavin Falkous and Shoichi Ishiura and Richard H Perry and Elaine K. Perry},
  journal={Journal of the Neurological Sciences},
  year={1995},
  volume={131},
  pages={65-70}
}
Recent evidence, based upon immunocytochemical and histochemical analysis of brain cortical tissue from alzheimer's disease patients, has suggested that altered activity and/or distribution of the lysosomal proteases cathepsins B and D may be implicated in the abnormal protein processing pathway resulting in formation of the neurotoxic amyloid A4 peptide, characteristic of this neurodegenerative disorder. We have therefore compared, via biochemical assay techniques using conventional or… CONTINUE READING
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