Comparison of cannabinoid binding sites in guinea-pig forebrain and small intestine.

@article{Ross1998ComparisonOC,
  title={Comparison of cannabinoid binding sites in guinea-pig forebrain and small intestine.},
  author={Ruth A. Ross and H C Brockie and Susanthi R. Fernando and Bijali Saha and Raj K. Razdan and Roger G Pertwee},
  journal={British journal of pharmacology},
  year={1998},
  volume={125 6},
  pages={1345-51}
}
We have investigated the nature of cannabinoid receptors in guinea-pig small intestine by establishing whether this tissue contains cannabinoid receptors with similar binding properties to those of brain CB1 receptors. The cannabinoids used were the CB1-selective antagonist SR141716A, the CB2-selective antagonist SR144528, the novel cannabinoid receptor ligand, 6'-azidohex-2'-yne-delta8-tetrahydrocannabinol (O-1184), and the agonists CP55940, which binds equally well to CB1 and CB2 receptors… CONTINUE READING

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