Comparison of cancer cells in 2D vs 3D culture reveals differences in AKT-mTOR-S6K signaling and drug responses.

@article{Riedl2017ComparisonOC,
  title={Comparison of cancer cells in 2D vs 3D culture reveals differences in AKT-mTOR-S6K signaling and drug responses.},
  author={Angelika Riedl and Michaela Schlederer and Karoline Pudelko and Mira Stadler and Stefanie Walter and Daniela Unterleuthner and Christine Unger and Nina Kramer and Markus Hengstschlaeger and Lukas Kenner and Dagmar Pfeiffer and Georg Krupitza and Helmut Dolznig},
  journal={Journal of cell science},
  year={2017},
  volume={130 1},
  pages={203-218}
}
Three-dimensional (3D) cancer models are used as preclinical systems to mimic physiologic drug responses. We provide evidence for strong changes of proliferation and metabolic capacity in three dimensions by systematically analyzing spheroids of colon cancer cell lines. Spheroids showed relative lower activities in the AKT, mammalian target of rapamycin… CONTINUE READING