Comparison of calibration strategies for the in vivo determination of absolute metabolite concentrations in the human brain by 31P MRS.

@article{Buchli1994ComparisonOC,
  title={Comparison of calibration strategies for the in vivo determination of absolute metabolite concentrations in the human brain by 31P MRS.},
  author={Reto Buchli and Eva L Martin and Peter Boesiger},
  journal={NMR in biomedicine},
  year={1994},
  volume={7 5},
  pages={225-30}
}
Cerebral concentrations of phosphorus metabolites can be assessed non-invasively by 31P MRS provided the metabolite signals are calibrated with the signal of a standard of known concentration. The reliability of the concentration estimates depends mainly on the strategy of calibration. Three strategies were compared by assessing the concentrations both in a test dummy and in the brain of volunteers. The first strategy utilized tissue water as an internal heteronuclear concentration standard… CONTINUE READING

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