Comparison of caffeine disposition following administration by oral solution (energy drink) and inspired powder (AeroShot) in human subjects

  title={Comparison of caffeine disposition following administration by oral solution (energy drink) and inspired powder (AeroShot) in human subjects},
  author={S. Laizure and B. Meibohm and Kembral Nelson and F. Chen and Zhe-yi Hu and R. B. Parker},
  journal={British Journal of Clinical Pharmacology},
AIMS To determine the disposition and effects of caffeine after administration using a new dosage form (AeroShot) that delivers caffeine by inspiration of a fine powder into the oral cavity and compare it to an equivalent dose of an oral solution (energy drink) as the reference standard. METHODS Healthy human subjects (n = 17) inspired a 100 mg caffeine dose using the AeroShot device or consumed an energy drink on separate study days. Heart rate, blood pressure and subject assessments of… Expand
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