Comparison of cDNA and genomic forms of tyrosine hydroxylase gene therapy of the brain with Trojan horse liposomes.

@article{Xia2007ComparisonOC,
  title={Comparison of cDNA and genomic forms of tyrosine hydroxylase gene therapy of the brain with Trojan horse liposomes.},
  author={Chun-fang Xia and Chun Chu and Jianyi Li and Yuntao Wang and Yun Zhang and Ruben J. Boado and William M Pardridge},
  journal={The journal of gene medicine},
  year={2007},
  volume={9 7},
  pages={605-12}
}
BACKGROUND The present study examines whether chromosomal derived forms of therapeutic genes can be delivered to brain following intravenous administration. The brain expression of a rat tyrosine hydroxylase (TH) cDNA is compared to the brain expression of a plasmid DNA encoding the 18 kb rat TH gene. METHODS TH gene expression is measured in cell culture and in vivo in brain in experimental Parkinson's disease (PD). A total of four eukaryotic expression plasmids encoding rat TH were… CONTINUE READING