Comparison of bromo- and iodoalkyl triflates for 18F-radiolabeling of amines.

@article{Chesis1990ComparisonOB,
  title={Comparison of bromo- and iodoalkyl triflates for 18F-radiolabeling of amines.},
  author={P L Chesis and Michael J. Welch},
  journal={International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes},
  year={1990},
  volume={41 3},
  pages={
          259-65
        }
}
  • P. L. Chesis, M. Welch
  • Published 1990
  • Chemistry
  • International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes
View on PubMed
doi.org
12 Citations

12 Citations

[18F]fluoromethyl triflate, a novel and reactive [18F]fluoromethylating agent: preparation and application to the on-column preparation of [18F]fluorocholine.
18F fluoroethylations: different strategies for the rapid translation of 11C-methylated radiotracers.
Development of an automated system for synthesizing 18F-labeled compounds using [18F]fluoroethyl bromide as a synthetic precursor.
Production and application of synthetic precursors labeled with carbon-11 and fluorine-18
TLDR
The use of solid-phase reactions to accomplish in a single step what would normally take several using conventional solvent-based reactions has already been shown to work in many occasions, and the obvious advantage here is that processes become more amenable to system automation thus affording greater reliability in day-to-day operations.
The Formation of the CF Bond: The Last Twelve Years
1 Introduction 2 Nucleophilic Fluorinating Reagents 3 Electrophilic Fluorinating Reagents 4 Synthesis of Compounds Containing The 18F Isotope For Use In Positron-Emitting Tomography 5…
Chemistry of β +-Emitting Compounds Based on Fluorine-18
TLDR
The aim of this review is to emphasise the scopes and limitations of the chemistry with fluorine-18 and the potential applications of the new 18F-radiopharmaceuticals are reviewed.
Development and Preclinical Evaulation of Novel Enzyme-targeting Radiotracers for Positron Emission Tomography
TLDR
This work sought to radiolabel novel positron-emitting radiotracers and evaluate their utility for quantifying enzymes relevant to neurological and psychiatric disorders via position emission tomography (PET) in preclinical studies and determined that [11C]PF-04457845 was a promising candidate which should be assessed in higher species.
Synthesis of 11C, 18F, 15O, and 13N radiolabels for positron emission tomography.
TLDR
This Review highlights key aspects of the synthesis of PET radiotracers with the short-lived positron-emitting radionuclides (11)C, (18)F, (15)O, and (13)N, with emphasis on the most recent strategies.
Syntheses and Uses of Isotopically Labelled Organic Halides
TLDR
In isotopically labelled organic halides - synthesis and uses, isotope effect studies with organic halide studies, and organic compounds labelled with astatine-211 synthesis are reviewed.
Synthese von 11C‐, 18F‐, 15O‐ und 13N‐Radiotracern für die Positronenemissionstomographie
Die Positronenemissionstomographie (PET) ist eine leistungsfahige Bildgebungsmethode, die zur Untersuchung und Visualisierung der menschlichen Physiologie eingesetzt wird. Das Funktionsprinzip der…
...
...

References

SHOWING 1-10 OF 26 REFERENCES
Synthesis of no-carrier-added N-([18F]fluoroalkyl)spiperone derivatives.
NCA 16α-[18F]fluoroestradiol-17β: The effect of reaction vessel on fluorine-18 resolubilization, product yield, and effective specific activity
A radiosynthesis of fluorine-18 fluoromisonidazole.
TLDR
The key feature of the reaction scheme is the preparation of a new fluoroalkylating agent, [18F]epifluorohydrin, which is useful for the production of 20-30 mCi quantities of this compound from [ 18F]fluoride.
Syntheses and D2 receptor affinities of derivatives of spiperone containing aliphatic halogens.
No-carrier-added (NCA) (+/-)-N-(3-[18F]fluoropropyl)-N-normetazocine-synthesis and PET studies in a baboon.
No-carrier-added 3-(2'-[18F]fluoroethyl)spiperone, a new dopamine receptor-binding tracer for positron emission tomography.
  • N. Satyamurthy, G. Bida, M. Phelps
  • Chemistry, Biology
    International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
  • 1986
[18F]fluoride from a small cyclotron for the routine synthesis of [18F]2-fluoro-2-deoxy-D-glucose.
Chemistry of fluorine-18 radiopharmaceuticals.
  • M. Berridge, T. Tewson
  • Chemistry
    International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes
  • 1986
N-(3-[18F]fluoropropyl)-spiperone: the preferred 18F labeled spiperone analog for positron emission tomographic studies of the dopamine receptor.
21-[18F]fluoro-16 alpha-ethyl-19-norprogesterone: synthesis and target tissue selective uptake of a progestin receptor based radiotracer for positron emission tomography.
TLDR
In vivo, [18F]FENP demonstrates highly selective, receptor-mediated uptake by the uterus of estrogen-primed rats, suggesting that this compound may be useful for the in vivo imaging of progestin target tissues and receptor-rich tumors by positron emission tomography.
...
...