Comparison of blood toluene levels after inhalation and oral administration.

  title={Comparison of blood toluene levels after inhalation and oral administration.},
  author={Martin J. P. Sullivan and Rory B. Conolly},
  journal={Environmental research},
  volume={45 1},
The purpose of this investigation was to compare blood toluene levels in Sprague-Dawley rats after oral and inhalation administration. Groups of 30 rats were dosed by gavage with 86.7, 217, 433, or 867 mg toluene/kg body wt or exposed for up to 6 hr, 5 rats per exposure, to an atmosphere of either 200 or 1000 ppm toluene. Blood was sampled by cardiac puncture from 5 rats in each of the six dose groups at 0.5, 1.0, 2.0, 4.0, 6.0, and 24.0 hr after gavage dosing or the beginning of the inhalation… CONTINUE READING


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