Comparison of bioavailability and phototoxicity of two oral preparations of 5-methoxypsoralen.

5-Methoxypsoralen (5-MOP) (Psoraderm 5) tablets obtained from France and 5-MOP micronized in capsules (manufactured in our pharmacy department) were administered to seven psoriasis patients in a 1.2 mg/kg body weight dose schedule. Bioavailability and phototoxicity were compared. It was found that the maximum serum concentration and the area under the… (More)