Comparison of behavioral and central BDZ binding profile in three rat lines.

@article{Onaivi1992ComparisonOB,
  title={Comparison of behavioral and central BDZ binding profile in three rat lines.},
  author={Emmanuel S. Onaivi and P A Maguire and Nu-man Tsai and Matthew F. Davies and Gilda H. Loew},
  journal={Pharmacology, biochemistry, and behavior},
  year={1992},
  volume={43 3},
  pages={825-31}
}
The performance of three widely used rat lines (Sprague-Dawley, Wistar, and Long Evans hooded) were evaluated in behavioral test systems that are sensitive to benzodiazepines. The in vivo effects of flunitrazepam and the brain [3H]Ro 15-1788 binding were determined and compared in these rat lines. The behavioral end points evaluated in this study were anxiolysis, measured using the automated elevated plus-maze; sedation by modification of locomotor activity; hyperphagia following food… CONTINUE READING

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