Comparison of approaches for parameter identifiability analysis of biological systems

@article{Raue2014ComparisonOA,
  title={Comparison of approaches for parameter identifiability analysis of biological systems},
  author={Andreas Raue and Johan Karlsson and Maria Pia Saccomani and Mats Jirstrand and Jens Timmer},
  journal={Bioinformatics},
  year={2014},
  volume={30 10},
  pages={
          1440-8
        }
}
  • Andreas Raue, Johan Karlsson, +2 authors Jens Timmer
  • Published in Bioinform. 2014
  • Computer Science, Medicine
  • MOTIVATION Modeling of dynamical systems using ordinary differential equations is a popular approach in the field of Systems Biology. The amount of experimental data that are used to build and calibrate these models is often limited. In this setting, the model parameters may not be uniquely determinable. Structural or a priori identifiability is a property of the system equations that indicates whether, in principle, the unknown model parameters can be determined from the available data… CONTINUE READING

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