Comparison of antihypertensive and metabolic effects of losartan and losartan in combination with hydrochlorothiazide--a randomized controlled trial.

@article{Owens2000ComparisonOA,
  title={Comparison of antihypertensive and metabolic effects of losartan and losartan in combination with hydrochlorothiazide--a randomized controlled trial.},
  author={Pe Owens and L Kelly and Ruth Nallen and Doug Ryan and Desmond FitzGerald and E. O'brien},
  journal={Journal of hypertension},
  year={2000},
  volume={18 3},
  pages={
          339-45
        }
}
INTRODUCTION Losartan is an angiotensin II receptor blocker indicated for treatment of hypertension. It also inhibits platelet agreggation through blockade of thromboxane A2/ prostaglandin H2 receptors, and has a uricosuric effect We determined the effect on ambulatory blood pressure (ABP) of 100 mg losartan monotherapy (L100) versus 50 mg losartan/12.5 mg hydrochlorothiazide (HCTZ) combination therapy (L50H12.5C), in patients uncontrolled on 50 mg losartan. We also assessed the effects of… CONTINUE READING

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