Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405, and GYKI 53655

@article{Szabados2001ComparisonOA,
  title={Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405, and GYKI 53655},
  author={Tam{\'a}s Szabados and G{\'a}bor Gigler and Istv{\'a}n Gacs{\'a}lyi and Istv{\'a}n Gyerty{\'a}n and Gy{\"o}rgy L{\'e}vay},
  journal={Brain Research Bulletin},
  year={2001},
  volume={55},
  pages={387-391}
}
Synthesis and evaluation of pharmacological properties of novel annelated 2,3-benzodiazepine derivatives.
TLDR
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TLDR
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AMPA receptor antagonists as potential anticonvulsant drugs.
Over the last years alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid glutamate receptors (AMPARs) have been intensively studied owing to their crucial role in physiological and pathological
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References

SHOWING 1-10 OF 23 REFERENCES
GYKI 52466 and related 2,3-benzodiazepines as anticonvulsant agents in DBA/2 mice.
Non-N-methyl-D-aspartate receptor antagonism by 3-N-substituted 2,3-benzodiazepines: relationship to anticonvulsant activity.
TLDR
The increased affinity of the 3-N-substituted analogs relates to their increased binding and decreased unbinding rates, which are inversely correlated with increasing blocking potency.
Cerebroprotective Effect of a Non–N‐Methyl‐D‐Aspartate Antagonist, GYKI 52466, After Focal Ischemia in the Rat
TLDR
The cerebroprotective effect of GYKI 52466 in the rat suggests a possible therapeutic role for non-N-methyl-D-aspartate antagonists given shortly after the onset of stroke.
Effects of the non‐NMDA antagonists NBQX and the 2,3‐benzodiazepine GYKI 52466 on different seizure types in mice: comparison with diazepam and interactions with flumazenil
TLDR
The data indicate that the GABAA receptor‐associated benzodiazepine site is not critically involved in anticonvulsant or adverse effects of GYKI 52466, and demonstrates that non‐NMDA antagonists lack a selective anticonVulsant action in standard models of generalized seizures.
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