Comparison of anticoagulant and procoagulant activities of stimulated platelets and platelet-derived microparticles.

@article{Tans1991ComparisonOA,
  title={Comparison of anticoagulant and procoagulant activities of stimulated platelets and platelet-derived microparticles.},
  author={Guido Tans and Jan Rosing and M Christella L G D Thomassen and M J Heeb and Robert F. A. Zwaal and J H Griffin},
  journal={Blood},
  year={1991},
  volume={77 12},
  pages={2641-8}
}
Activation of human platelets considerably enhanced their ability to accelerate factor Va inactivation by activated protein C (APC). The anticoagulant activity of platelet suspensions was markedly dependent on the kind of agonist used to activate platelets. APC-catalyzed factor Va inactivation in free solution was characterized by an apparent second-order rate constant of 2 x 10(5) (mol/L)-1 (seconds)-1. Nonstimulated platelets (2.4 x 10(8)/mL) and platelets stimulated with adenosine… CONTINUE READING