Comparison of antiarrhythmic drug therapy and radiofrequency catheter ablation in patients with paroxysmal atrial fibrillation: a randomized controlled trial.

@article{Wilber2010ComparisonOA,
  title={Comparison of antiarrhythmic drug therapy and radiofrequency catheter ablation in patients with paroxysmal atrial fibrillation: a randomized controlled trial.},
  author={David J. Wilber and Carlo Pappone and Petr Neu{\vz}il and Angelo Amato Vincenzo de Paola and Frank E Marchlinski and Andrea Natale and Laurent Macle and Emile G Daoud and Hugh Calkins and Burr Hall and Vivek Reddy and Giuseppe Augello and Matthew R. Reynolds and Chandan Vinekar and Christine Y Liu and Scott M F Berry and Donald A. Berry},
  journal={JAMA},
  year={2010},
  volume={303 4},
  pages={333-40}
}
CONTEXT Antiarrhythmic drugs are commonly used for prevention of recurrent atrial fibrillation (AF) despite inconsistent efficacy and frequent adverse effects. Catheter ablation has been proposed as an alternative treatment for paroxysmal AF. OBJECTIVE To determine the efficacy of catheter ablation compared with antiarrhythmic drug therapy (ADT) in treating symptomatic paroxysmal AF. DESIGN, SETTING, AND PARTICIPANTS A prospective, multicenter, randomized (2:1), unblinded, Bayesian-designed… CONTINUE READING

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  • V Fuster, LE Rydén, DS Cannom
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