Corpus ID: 36480233

Comparison of anti-allergic activities of the histamine H1 receptor antagonists epinastine, ketotifen and oxatomide in human leukocytes.

@article{Mita1995ComparisonOA,
  title={Comparison of anti-allergic activities of the histamine H1 receptor antagonists epinastine, ketotifen and oxatomide in human leukocytes.},
  author={H. Mita and T. Shida},
  journal={Arzneimittel-Forschung},
  year={1995},
  volume={45 1},
  pages={
          36-40
        }
}

• H. Mita, T. Shida
• Published 1995
• Chemistry, Medicine
• Arzneimittel-Forschung

The effects of three histamine H1 receptor antagonists, epinastine (CAS 80012-43-7, WAL-801 CL), ketotifen (CAS 34580-13-7) and oxatomide (CAS 60607-34-3), on mediator release have been studied in human peripheral leukocytes. When leukocytes from asthmatic patients sensitive to mite were stimulated with the allergen, epinastine inhibited histamine release with a concentration required for 50% inhibition (IC50) of 3 x 10(-5) mol/l and leukotriene C4 generation. On the other hand, ketotifen or… Expand

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