Comparison of anti 60 and 52 kDa SS-A/Ro antibodies in the pathogenesis of cutaneous lupus erythematosus.

@article{Yoshimasu2002ComparisonOA,
  title={Comparison of anti 60 and 52 kDa SS-A/Ro antibodies in the pathogenesis of cutaneous lupus erythematosus.},
  author={Takashi Yoshimasu and Akihisa Hiroi and Toshio Ohtani and Koji Uede and Fukumi Furukawa},
  journal={Journal of dermatological science},
  year={2002},
  volume={29 1},
  pages={35-41}
}
Anti SS-A/Ro antibodies are involved in the pathogenesis of cutaneous lupus erythematosus (CLE) in a part through antibody dependent cellular cytotoxicity (ADCC). However, it is still obscure which and how anti 60 and anti 52 kDa Ro antibodies are involved. To address the issue, we examined both types of anti Ro antibodies of sera from patients with systemic LE (SLE) or discoid LE (LE). The titer of anti 60 kDa antibody in SLE was significantly much higher than that of DLE or control. The… CONTINUE READING