Comparison of antacid, sucralfate, cimetidine, and ranitidine in protection of the gastric mucosa against ethanol injury.

@article{Tarnawski1985ComparisonOA,
  title={Comparison of antacid, sucralfate, cimetidine, and ranitidine in protection of the gastric mucosa against ethanol injury.},
  author={Andrzej S. Tarnawski and Daniel den Hollander and Hella Gergely and Jerzy Stachura},
  journal={The American journal of medicine},
  year={1985},
  volume={79 2C},
  pages={19-23}
}
The abilities of antacid (Mylanta II), sucralfate, cimetidine, and ranitidine to protect the gastric mucosa against ethanol-induced necrosis were compared in a standardized, experimental rat model. Fasted rats received pretreatment with either saline, Mylanta II, 500 mg/kg of sucralfate, 50 mg/kg of cimetidine, or 50 mg/kg of ranitidine. This was followed one hour later by intragastric administration of 2 ml of 100 percent ethanol. Gastric mucosal injury was assessed four hours after… CONTINUE READING