Comparison of angiotensin-converting enzyme (ACE), neutral endopeptidase (NEP) and dual ACE/NEP inhibition on blood pressure and resistance arteries of deoxycorticosterone acetate-salt hypertensive rats

@article{Pu2002ComparisonOA,
  title={Comparison of angiotensin-converting enzyme (ACE), neutral endopeptidase (NEP) and dual ACE/NEP inhibition on blood pressure and resistance arteries of deoxycorticosterone acetate-salt hypertensive rats},
  author={Qian Pu and Rhian M. Touyz and Ernesto L Schiffrin},
  journal={Journal of Hypertension},
  year={2002},
  volume={20},
  pages={899-907}
}
Objectives Omapatrilat, an inhibitor of neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE), is an effective antihypertensive agent. Here, we studied the relative roles of NEP and ACE inhibition and their effect on resistance artery structure and function of deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Methods Omapatrilat (40 mg/kg per day), the NEP inhibitor CGS 25462 (CGS, 100 mg/kg per day) and the ACE inhibitor enalapril (10 mg/kg per day), were given for 3… Expand
Dual angiotensin-converting enzyme/neutral endopeptidase inhibition on cardiac and renal fibrosis and inflammation in DOCA-salt hypertensive rats
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Omapatrilat increases renal endothelin in deoxycorticosterone acetate-salt hypertensive rats.
TLDR
It is indicated that combined ACE/NEP inhibition does not lower blood pressure in a model of established hypertension with high ET activity and the hypothesis that combinedACE/Nep inhibition can increase renal ET production is supported. Expand
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The Effect of Acute Angiotensin-Converting Enzyme and Neutral Endopeptidase 24.11 Inhibition on Plasma Extravasation in the Rat
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It is shown that ACE inhibitor-induced plasma extravasation is enhanced by concomitant inhibition of NEP, and this study is the first to relate the degree of ACE and/or NEP inhibition toextravasation liability in the rat model. Expand
Vascular and renal effects of vasopeptidase inhibition and angiotensin-converting enzyme blockade in spontaneously diabetic Goto-Kakizaki rats
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Despite comparable blood pressure-lowering and renoprotective properties, omapatrilat may be more effective in preventing vascular dysfunction during diabetes compared to enalapril in GK rats. Expand
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TLDR
OMA is marginally more potent compared with ENP alone in lowering blood pressure and preventing cardiovascular and renal injury and vasopeptidase inhibition is not superior to ACE inhibition in the prevention of cardiovascular and kidney damage Goldblatt hypertension. Expand
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TLDR
Omapatrilat treatment significantly reduced left ventricular hypertrophy and improved endothelial function in carotid arteries from male SHRSP by NO-dependent mechanisms. Expand
Attenuation of Cardiovascular Remodeling in DOCA-Salt Rats by the Vasopeptidase Inhibitor, Omapatrilat
TLDR
It is concluded that the renin-angiotensin-aldosterone, natriuretic peptide, and bradykinin systems are directly involved in the pathogenesis of cardiovascular remodeling in the DOCA-salt model of hypertension in rats, which may be independent of their effects on blood pressure. Expand
Direct inhibition of neutral endopeptidase in vasopeptidase inhibitor-mediated amelioration of cardiac remodeling in rats with chronic heart failure
TLDR
The results suggest that vasopeptidase inhibitor suppressed cardiac remodeling in the setting of chronic heart failure, possibly acting through the direct inhibition of cardiac NEP. Expand
Role of neutral endopeptidase and angiotensin-converting enzyme in deoxycorticosterone acetate-salt hypertension.
The deoxycorticosterone acetate (DOCA)-salt hypertensive rat represents a volume-dependent, low renin model of hypertension. Therefore, inhibitors of the renin–angiotensin system are not veryExpand
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