Comparison of analgesic effect of 24% sucrose and breast milk in healthy infants less than 2 months of age

  title={Comparison of analgesic effect of 24\% sucrose and breast milk in healthy infants less than 2 months of age},
  author={S. Kavthekar and R. Patil and A. B. Kurane and H. Bharati},
  journal={International Journal of Contemporary Pediatrics},
Background: Many newborns undergo painful procedures like heel pricks, venepuncture and intramuscular injection for immunization. The medical and paramedical staffs usually ignore pain felt during these procedures. The aim of this study was to compare analgesic activity of 24% sucrose solution with breast milk during 1st DPT vaccination using sterile water as placebo. Methods: This double blind, randomized placebo controlled trial was conducted in 150 healthy infants undergoing for their 1 st… Expand
Treating pain during vaccination should be a part of pediatric primary health care around the world, as untreated pain in children has short and long-term consequences. Few studies of pharmacologicExpand
Oral Sucrose Versus Breastfeeding in Managing Infants' Immunization-Related Pain: A Randomized Controlled Trial
There were significant differences in pain scores and crying duration during and after immunization for the breastfeeding group compared with the sucrose and control groups and more studies are needed to evaluate effectiveness of breastfeeding versus other pain management methods for managing infants' immunization-related pain. Expand
Nonpharmacological Methods for Reducing Parental Concern for Infant Vaccine-Associated Pain.
  • Mona Abukhaled, Susan E Cortez
  • Medicine
  • Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners
  • 2020
Nurses can effectively use nonpharmacological methods to alleviate the pain of infants undergoing routine vaccination while reducing the parental concern for vaccine-associated pain. Expand
Comparison of analgesic effect of 24% sucrose and breast milk in healthy infants less than 2 months of age
24% Sucrose and breast milk had analgesic activity in infants less than two months of age undergoing DPT vaccination, and the analgesic effect was better for 24% sucrose as compared to breast milk. Expand


The analgesic effect of sucrose in full term infants: a randomised controlled trial
Concentrated sucrose solution seems to reduce crying and the autonomic effects of a painful procedure in healthy normal babies and Sucrose may be a useful and safe analgesic for minor procedures in neonates. Expand
Reduction of neonatal pain following administration of 25% lingual dextrose: a randomized control trial.
Lingual 25% dextrose is an effective analgesic for relieving pain during orogastric tube insertion following oropharyngeal infant feeding tube insertions in neonates admitted to Neonatal Intensive Care Unit. Expand
Analgesic Properties of Oral Sucrose During Routine Immunizations at 2 and 4 Months of Age
Oral sucrose is an effective, easy-to-administer, short-acting analgesic for use during routine immunizations in infants at 2 and 4 months of age and shows reductions in pain scores 2 minutes after solution administration. Expand
Effect of breastfeeding during venepuncture in neonates
It has been demonstrated that breastfeeding is analgesic in neonates during venepuncture and previous venep punctures and site of venepunctures do not seem to affect pain scores, and breastfeeding should be the first-choice analgesic during painful procedures in Neonates. Expand
The use of breast-feeding for pain relief during neonatal immunization injections.
It was concluded that breast-feeding, maternal holding, and skin-to-skin contact significantly reduced crying in infants receiving an immunization injection for diphtheria, tetanus, and pertussis. Expand
Sucrose as an analgesic for newborn infants.
These findings, which parallel results obtained in studies of pain in infant rats, provide a potent yet simple, benign intervention to help alleviate stress and pain routinely experienced by human infants. Expand
To evaluate and compare the efficacy of combined sucrose and non-nutritive sucking for analgesia in newborns undergoing minor painful procedure: a randomized controlled trial
Sucrose and/or NNS are effective in providing analgesia in full-term neonates undergoing heel-stick procedures, with the combined intervention being more effective compared with any single intervention. Expand
Reduction of pain response in premature infants using intraoral sucrose.
There was a significant reduction in the duration of first cry, the percentage of time spent crying in the 5 minutes after heel prick, and the pain score in the sucrose treated group. Expand
Breastfeeding or breast milk for procedural pain in neonates.
The effectiveness of breastfeeding or supplemental breast milk in reducing procedural pain in neonates was evaluated and breast milk was found not to be effective in reducing validated and non-validated pain scores such as NIPS, NFCS, and PIPP. Expand
Sucrose for Procedural Pain Management in Infants
What is known about the mechanisms of sucrose-induced analgesia is reviewed; existing evidence, knowledge gaps, and current controversies are highlighted; and directions for future research and practice are provided. Expand