Comparison of ampicillin plus gentamicin vs. penicillin plus gentamicin in empiric treatment of neonates at risk of early onset sepsis.

@article{Metsvaht2010ComparisonOA,
  title={Comparison of ampicillin plus gentamicin vs. penicillin plus gentamicin in empiric treatment of neonates at risk of early onset sepsis.},
  author={Tuuli Metsvaht and M-L Ilmoja and {\"U}lle Parm and Lea Maipuu and Mirjam Merila and Irja Lutsar},
  journal={Acta paediatrica},
  year={2010},
  volume={99 5},
  pages={665-672}
}
AIM We aimed to compare the clinical efficacy of ampicillin (AMP) vs. penicillin (PEN) both combined with gentamicin in the empirical treatment of neonates at risk of early onset neonatal sepsis (EOS). METHODS We performed an open label cluster randomized equivalence study in both Estonian neonatal intensive care units, including neonates with suspected EOS, aged less than 72 h. Primary end-point was clinical failure rate, expressed by need for change of antibiotic regimen within 72 h and/or… CONTINUE READING

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