Comparison of alternative buffers for use with a new live oral cholera vaccine, Peru-15, in outpatient volunteers.


During development of Peru-15, a new live oral vaccine for cholera, the role of buffer needed to be evaluated. Generally, oral bacterial vaccines are acid labile and need to be administered by using a formulation which protects them from gastric acid. We compared three different buffers for use with Peru-15, including a standard bicarbonate-ascorbic acid… (More)


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