Comparison of alterations of chromosome 17 in carcinoma of the ovary and of the breast

  title={Comparison of alterations of chromosome 17 in carcinoma of the ovary and of the breast},
  author={Rosmarie F Caduff and Suzette M. Svoboda-Newman and Amy W. Ferguson and Thomas S. Frank},
  journal={Virchows Archiv},
 Breast and ovarian carcinomas share a region of allelic loss on chromosome 17q25, suggesting that these tumours may arise by similar molecular pathways. We analysed paraffin-embedded tissues from 84 sporadic ovarian carcinomas and 42 sporadic infiltrating ductal carcinomas of the breast for abnormalities on chromosome 17. Loss of heterozygosity (LOH) of at least one informative marker on 17q was identified in 49 of 82 (60%) ovarian carcinomas, as against only 6 of 40 (15%) informative breast… CONTINUE READING


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