Comparison of alpha 1-adrenergic receptor-stimulated inositol phosphate formation in primary neuronal and glial cultures.

@article{Wilson1990ComparisonOA,
  title={Comparison of alpha 1-adrenergic receptor-stimulated inositol phosphate formation in primary neuronal and glial cultures.},
  author={Keith M. Wilson and Sandra Gilchrist and Kenneth P. Minneman},
  journal={Journal of neurochemistry},
  year={1990},
  volume={55 2},
  pages={
          691-7
        }
}
alpha 1-Adrenergic receptor binding sites and norepinephrine-stimulated 3H-inositol phosphate (3H-InsP) accumulation were measured in primary cultures of neurons and glia from 1-day-old rat brains. The density of alpha 1-adrenergic receptor binding sites was approximately three times higher in membranes from neurons compared to glia. Although norepinephrine was slightly more potent in stimulating 3H-InsP formation in neurons than in glia, the maximal response was greater in glial cells… CONTINUE READING

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