Comparison of alkylation rates and mutagenicity of directly acting industrial and laboratory chemicals

@article{Hemminki1980ComparisonOA,
  title={Comparison of alkylation rates and mutagenicity of directly acting industrial and laboratory chemicals},
  author={Kari Hemminki and K. Falck and Harri Vainio},
  journal={Archives of Toxicology},
  year={1980},
  volume={46},
  pages={277-285}
}
Groups of industrial and laboratory chemicals were tested for their alkylation activity using 4-(p-nitrobenzyl)-pyridine and deoxyguanosine as nucleophiles. The alkylation activity was compared with mutagenicity of the chemicals to E. coli WP2 uvrA without metabolic activation. All the epoxide-containing compounds including simple epoxides and glycidyl ethers elicited alkylation activity and mutagenicity. Furthermore there was a reasonable correlation between the rate of alkylation and the… CONTINUE READING

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Correlation of mutagenicity and 4( pnitrobenzyl )pyridine alkylation by epoxides

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Correlation of mutagenicity and 4-(p-nitrobenzyl)-pyridine

K Hemminki, K Falck
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