Comparison of agents that affect aldosterone action.


The first aldosterone blocker, spironolactone, initially was used as a diuretic but was accompanied by a significant amount of side effects that necessitated the withdrawal of the drug in a relevant number of patients. The discovery of the many receptor-mediated actions of aldosterone in several different organs greatly contributed to expand the indications… (More)
DOI: 10.1016/j.semnephrol.2014.04.005


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