Comparison of adeno-associated virus serotypes and delivery methods for cardiac gene transfer.

@article{Fang2012ComparisonOA,
  title={Comparison of adeno-associated virus serotypes and delivery methods for cardiac gene transfer.},
  author={Hongfei Fang and Ngai Chin Lai and Mei Hua Gao and Atsushi Miyanohara and David M Roth and Tong Gao Tang and H Kirk Hammond},
  journal={Human gene therapy methods},
  year={2012},
  volume={23 4},
  pages={234-41}
}
Cardiac gene transfer is a potentially useful strategy for cardiovascular diseases. The adeno-associated virus (AAV) is a common vector to obtain transgene expression in the heart. Initial studies conducted in rodents used indirect intracoronary delivery for cardiac gene transfer. More recently AAV vectors with so-called cardiac tropism have enabled significant cardiac transgene expression following intravenous injection. However, a direct comparison of intravenous versus intracoronary delivery… CONTINUE READING
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