Comparison of acute ozone-induced nasal and pulmonary inflammatory responses in rats.

@article{Hotchkiss1989ComparisonOA,
  title={Comparison of acute ozone-induced nasal and pulmonary inflammatory responses in rats.},
  author={John A Hotchkiss and Jack R. Harkema and James D. Sun and Rogene F. Henderson},
  journal={Toxicology and applied pharmacology},
  year={1989},
  volume={98 2},
  pages={289-302}
}
The centriacinar pulmonary lesion induced by ozone has been extensively characterized, but little is known about the effects of this oxidant gas in the upper airways. The present study was designed to compare the effects of acute ozone exposure in the nose and lungs of rats. We examined the cellular inflammatory responses in the nasal cavity and lower respiratory tract by means of nasal and bronchoalveolar lavage and morphometric quantitation of neutrophils within the nasal mucosa and pulmonary… CONTINUE READING

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