Comparison of acute and subacute effects of deflazacort and prednisone on glucose metabolism in man

  title={Comparison of acute and subacute effects of deflazacort and prednisone on glucose metabolism in man},
  author={Paolo Cavallo-Perin and Alberto Bruno and Alessandro Ozzello and Anna Maria Dall'omo and A. Lombardi and Maurizio Cassader and Bruno Pietro Imbimbo and Gianfranco Pagano},
  journal={European Journal of Clinical Pharmacology},
SummaryCorticosteroid treatment produces glucose intolerance with insulin resistance. Recent reports have indicated that deflazacort (DF) is significantly less diabetogenic than prednisone (PN). A euglycaemic hyperinsulinaemic (100 µU/ml) glucose clamp (EHGC) and 3H-glucose infusion for 240 min were performed in 6 healthy volunteers (HV) after administration of 15 mg PN or 18 mg DF, 12 h and 2 h before test. The glucose metabolic clearance rate (MCR) was significantly (p=0.02) higher after DF… 
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