Comparison of accumulated allele loss between primary tumor and lymph node metastasis in stage II non-small cell lung carcinoma: implications for the timing of lymph node metastasis and prognostic value.

@article{Sasatomi2002ComparisonOA,
  title={Comparison of accumulated allele loss between primary tumor and lymph node metastasis in stage II non-small cell lung carcinoma: implications for the timing of lymph node metastasis and prognostic value.},
  author={Eizaburo Sasatomi and Sydney D. Finkelstein and Jeffrey D Woods and Anke Bakker and Patricia A. Swalsky and James D. Luketich and H. C. Fernando and Samuel A. Yousem},
  journal={Cancer research},
  year={2002},
  volume={62 9},
  pages={2681-9}
}
Although the Tumor-Node-Metastasis staging of non-small cell lung carcinoma (NSCLC) is the most effective predictor of survival, the clinical outcome of patients at each stage is variable on an individual case basis. We tested the value of incorporating information about the tumor heterogeneity of NSCLC into microsatellite allelotyping in a cohort of 48 node-positive stage II patients (T1N1M0 and T2N1M0). Microsatellite allelotyping involved microdissection of the invasive component of primary… CONTINUE READING