Comparison of a single infusion of zoledronic acid with risedronate for Paget's disease.

  title={Comparison of a single infusion of zoledronic acid with risedronate for Paget's disease.},
  author={Ian R Reid and Paul D E Miller and Kenneth W. Lyles and W. D. Fraser and Jacques P Brown and Youssef Saidi and Peter G Mesenbrink and Guoqin Su and Judy Pak and Ken Zelenakas and Monica E Luchi and Peter Richardson and David Hosking},
  journal={The New England journal of medicine},
  volume={353 9},
BACKGROUND The advent of bisphosphonates advanced therapy for Paget's disease, but more effective and convenient agents are needed to increase adherence. Zoledronic acid, a bisphosphonate administered as a single intravenous infusion, might meet these needs. METHODS In two identical, randomized, double-blind, actively controlled trials of 6 months' duration, we compared one 15-minute infusion of 5 mg of zoledronic acid with 60 days of oral risedronate (30 mg per day). The primary efficacy end… CONTINUE READING


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