Comparison of a once-a-day sustained-release morphine formulation with standard oral morphine treatment for cancer pain.

@article{Broomhead1997ComparisonOA,
  title={Comparison of a once-a-day sustained-release morphine formulation with standard oral morphine treatment for cancer pain.},
  author={A F Broomhead and R. Kerr and William Tester and P O'meara and C. Maccarrone and Ross Bowles and P G Hodsman},
  journal={Journal of pain and symptom management},
  year={1997},
  volume={14 2},
  pages={63-73}
}
Kadian/Kapanol (K) is a capsule formulation of morphine designed for 12- or 24-hourly dosing. This double-blind study compared the efficacy and safety of K every 24 hr to K every 12 hr and MS Contin tablets (MSC) every 12 hr. One hundred fifty-two patients with cancer pain were titrated to adequate analgesia with immediate-release morphine (IRM) solution. Stabilized patients were randonized to one of the three treatments for 7 +/- 1 days. Rescue medication was IRM tablets. Efficacy and safety… CONTINUE READING

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