Comparison of Tissue Metal Concentrations in Zucker Lean, Zucker Obese, and Zucker Diabetic Fatty Rats and the Effects of Chromium Supplementation on Tissue Metal Concentrations

@article{Staniek2012ComparisonOT,
  title={Comparison of Tissue Metal Concentrations in Zucker Lean, Zucker Obese, and Zucker Diabetic Fatty Rats and the Effects of Chromium Supplementation on Tissue Metal Concentrations},
  author={Halina Staniek and Nicholas R. Rhodes and Kristin R. Di Bona and Ge Deng and Sharifa T. Love and Leigh Ann Pledger and Jeremy Blount and Emmalea Gomberg and Frances Grappe and Chelsea Cernosek and Brittany D Peoples and Jane F. Rasco and Zbigniew Krejpcio and John B Vincent},
  journal={Biological Trace Element Research},
  year={2012},
  volume={151},
  pages={373-383}
}
Diabetes results in several metabolic changes, including alterations in the transport, distribution, excretion, and accumulation of metals. While changes have been examined in several rat models of insulin resistance and diabetes, the metal ion concentrations in the tissues of Zucker lean, Zucker obese (an insulin resistance and early stage diabetes model), and Zucker diabetic fatty (ZDF, a type 2 diabetes model) have not previously been examined in detail. The concentration of Cu, Zn, Fe, Mg… CONTINUE READING