Comparison of Three Regimens for Treatment of Mild to Moderate Pneumocystis carinii Pneumonia in Patients with AIDS: A Double-Blind, Randomized Trial of Oral Trimethoprim-Sulfamethoxazole, Dapsone-Trimethoprim, and Clindamycin-Primaquine

@article{Safrin1996ComparisonOT,
  title={Comparison of Three Regimens for Treatment of Mild to Moderate Pneumocystis carinii Pneumonia in Patients with AIDS: A Double-Blind, Randomized Trial of Oral Trimethoprim-Sulfamethoxazole, Dapsone-Trimethoprim, and Clindamycin-Primaquine},
  author={S. Safrin and D. Finkelstein and J. Feinberg and P. Frame and G. Simpson and A. Wu and T. Cheung and Ruy Soiero and P. Hojczyk and J. Black},
  journal={Annals of Internal Medicine},
  year={1996},
  volume={124},
  pages={792-802}
}
  • S. Safrin, D. Finkelstein, +7 authors J. Black
  • Published 1996
  • Medicine
  • Annals of Internal Medicine
  • *For additional members of the ACTG 108 study group, see the Appendix. In 1994, 15 440 cases of Pneumocystis carinii pneumonia occurring in the United States were reported to the Centers for Disease Control and Prevention [1]. Thus, despite the advent of prophylactic agents to prevent this infection, the need for effective and nontoxic therapeutic regimens remains. Increased physician and patient awareness, along with improved methods of diagnosis, have made earlier institution of ambulatory… CONTINUE READING
    164 Citations

    Paper Mentions

    Interventional Clinical Trial
    To evaluate the effectiveness of two oral treatments for mild to moderate Pneumocystis carinii pneumonia (PCP): dapsone/trimethoprim or clindamycin/primaquine as compared to a… Expand
    ConditionsHIV Infections, Pneumonia, Pneumocystis Carinii
    InterventionDrug
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    • W. Hughes
    • Medicine
    • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
    • 1998
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    References

    SHOWING 1-10 OF 26 REFERENCES
    Oral therapy for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. A controlled trial of trimethoprim-sulfamethoxazole versus trimethoprim-dapsone.
    • 276
    • Highly Influential
    Clindamycin and primaquine therapy for mild-to-moderate episodes of Pneumocystis carinii pneumonia in patients with AIDS: AIDS Clinical Trials Group 044.
    • 44
    Dapsone-trimethoprim for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome.
    • 142
    Clindamycin/primaquine versus trimethoprim-sulfamethoxazole as primary therapy for Pneumocystis carinii pneumonia in AIDS: a randomized, double-blind pilot trial.
    • 51
    Comparison of atovaquone (566C80) with trimethoprim-sulfamethoxazole to treat Pneumocystis carinii pneumonia in patients with AIDS.
    • 241