Comparison of T-cell responses in self-limiting versus progressive visceral Leishmania donovani infections in golden hamsters.

@article{Gifawesen1989ComparisonOT,
  title={Comparison of T-cell responses in self-limiting versus progressive visceral Leishmania donovani infections in golden hamsters.},
  author={C Gifawesen and Jay P. Farrell},
  journal={Infection and immunity},
  year={1989},
  volume={57 10},
  pages={3091-6}
}
Leishmania donovani infection in golden hamsters was studied as a model for human kala-azar. After intradermal inoculation of L. donovani amastigotes, hamsters developed positive skin reactions (delayed-type hypersensitivity [DTH]) to parasite antigens and lymphoid cells from these hamsters proliferated to parasite antigens in vitro and transferred DTH reactivity to normal recipients. In contrast, hamsters infected by the intracardial route developed progressive visceral infections and failed… CONTINUE READING

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Phytohemagglutinininduced lymphocyte transformation test in Indian kala-azar

A. C. Ghose, S. C. Haldar
Trans. R. Soc. Trop. Med • 1979

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